[HTML][HTML] Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders
Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of
anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective
effect against castor oil-induced diarrhoea in mice at 100–1000 mg/kg. In rabbit jejunum
preparations, JeExt (0.01–1.0 mg/mL) caused relaxation of spontaneous and K+(80 mM)-
induced contractions at similar concentrations to papaverine, whereas verapamil was
relatively more potent against K+. JeExt (0.03–0.3 mg/mL) shifted Ca 2+ concentration …
anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective
effect against castor oil-induced diarrhoea in mice at 100–1000 mg/kg. In rabbit jejunum
preparations, JeExt (0.01–1.0 mg/mL) caused relaxation of spontaneous and K+(80 mM)-
induced contractions at similar concentrations to papaverine, whereas verapamil was
relatively more potent against K+. JeExt (0.03–0.3 mg/mL) shifted Ca 2+ concentration …
Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders.
MK Munasib Khan, AUK Arif-Ullah Khan… - 2012 - cabidigitallibrary.org
Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of
anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective
effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum
preparations, JeExt (0.01-1.0 mg/mL) caused relaxation of spontaneous and K+ (80 mM)-
induced contractions at similar concentrations to papaverine, whereas verapamil was
relatively more potent against K+. JeExt (0.03-0.3 mg/mL) shifted Ca2+ concentration …
anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective
effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum
preparations, JeExt (0.01-1.0 mg/mL) caused relaxation of spontaneous and K+ (80 mM)-
induced contractions at similar concentrations to papaverine, whereas verapamil was
relatively more potent against K+. JeExt (0.03-0.3 mg/mL) shifted Ca2+ concentration …
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