Phenotypic plasticity and cell fate decisions in cancer: insights from dynamical systems theory

D Jia, MK Jolly, P Kulkarni, H Levine - Cancers, 2017 - mdpi.com
… Using epithelial-to-mesenchymal transition (EMT), cancer stem-like properties, metabolic …
illustrate how phenotypic plasticity in cancer cells enables them to acquire hybrid phenotypes (…

Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics

A Uthamacumaran - Biological Cybernetics, 2022 - Springer
… heterogeneous cellular states and phenotypic plasticity are … allows clinical medicine to adopt
a dynamical systems … tumors as dynamical systems are suggested to pave dynamical and (…

Epigenetics as a mediator of plasticity in cancer

AP Feinberg, A Levchenko - Science, 2023 - science.org
… This strategy has yielded new insights whereby stochastic … for our understanding of phenotypic
plasticity. Multiple questions … cell fate–specifying molecular circuits, but also with specific …

Roadmap on plasticity and epigenetics in cancer

J Foo, D Basanta, RC Rockne, C Strelez… - Physical …, 2022 - iopscience.iop.org
phenotypic plasticity in cancer progression as well as discussing ways of translating these
ideas … In summary, generic dynamical systems principles without a specific model suggest that …

Cell fate dynamics reconstruction identifies TPT1 and PTPRZ1 feedback loops as master regulators of differentiation in pediatric glioblastoma-immune cell networks

A Uthamacumaran - Interdisciplinary Sciences: Computational Life …, 2024 - Springer
… Complex systems are irreducible dynamical systems composed of … This dispersion provides
insight into the multiscale … driving glioblastoma phenotypic plasticity and cellcell crosstalk …

A review of mathematical and computational methods in cancer dynamics

A Uthamacumaran, H Zenil - Frontiers in oncology, 2022 - frontiersin.org
… network patterns/dynamics steering cancer cell fate decision-making… of dynamical systems
theory applications in cancer research … cancer stemness networks and phenotypic plasticity in …

Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma

M Pillai, MK Jolly - IScience, 2021 - cell.com
… mechanistic insights into the roles of these individual molecules in phenotypic plasticity in …
However, these interactions have not been investigated from a dynamical systems perspective …

Stochastic population dynamics of cancer stemness and adaptive response to therapies

P Jain, AS Duddu, MK Jolly - Essays in Biochemistry, 2022 - portlandpress.com
… various processes underlying phenotypic plasticity such as … Such a dynamical systems
approach to elucidating patterns of … Such dynamic insights can be valuable in deciding

Quantifying cancer cell plasticity with gene regulatory networks and single-cell dynamics

SM Groves, V Quaranta - Frontiers in Network Physiology, 2023 - frontiersin.org
Phenotypic plasticity of cancer cells can lead to complex cell … In dynamical systems theory,
plasticity is a weaker kind of … plasticity as multipotency by defining possible cell fates for each …

Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again!

DJ Wooten, V Quaranta - … et Biophysica Acta (BBA)-Reviews on Cancer, 2017 - Elsevier
… tool to obtain a “rough and ready picture” that “cannot be interpreted rigorously” [17], it
was nonetheless developed within the mathematical context of dynamical systems theory. …