Phenotypic plasticity and cell fate decisions in cancer: insights from dynamical systems theory
… Using epithelial-to-mesenchymal transition (EMT), cancer stem-like properties, metabolic …
illustrate how phenotypic plasticity in cancer cells enables them to acquire hybrid phenotypes (…
illustrate how phenotypic plasticity in cancer cells enables them to acquire hybrid phenotypes (…
Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics
A Uthamacumaran - Biological Cybernetics, 2022 - Springer
… heterogeneous cellular states and phenotypic plasticity are … allows clinical medicine to adopt
a dynamical systems … tumors as dynamical systems are suggested to pave dynamical and (…
a dynamical systems … tumors as dynamical systems are suggested to pave dynamical and (…
Epigenetics as a mediator of plasticity in cancer
AP Feinberg, A Levchenko - Science, 2023 - science.org
… This strategy has yielded new insights whereby stochastic … for our understanding of phenotypic
plasticity. Multiple questions … cell fate–specifying molecular circuits, but also with specific …
plasticity. Multiple questions … cell fate–specifying molecular circuits, but also with specific …
Roadmap on plasticity and epigenetics in cancer
… phenotypic plasticity in cancer progression as well as discussing ways of translating these
ideas … In summary, generic dynamical systems principles without a specific model suggest that …
ideas … In summary, generic dynamical systems principles without a specific model suggest that …
Cell fate dynamics reconstruction identifies TPT1 and PTPRZ1 feedback loops as master regulators of differentiation in pediatric glioblastoma-immune cell networks
A Uthamacumaran - Interdisciplinary Sciences: Computational Life …, 2024 - Springer
… Complex systems are irreducible dynamical systems composed of … This dispersion provides
insight into the multiscale … driving glioblastoma phenotypic plasticity and cell–cell crosstalk …
insight into the multiscale … driving glioblastoma phenotypic plasticity and cell–cell crosstalk …
A review of mathematical and computational methods in cancer dynamics
A Uthamacumaran, H Zenil - Frontiers in oncology, 2022 - frontiersin.org
… network patterns/dynamics steering cancer cell fate decision-making… of dynamical systems
theory applications in cancer research … cancer stemness networks and phenotypic plasticity in …
theory applications in cancer research … cancer stemness networks and phenotypic plasticity in …
Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma
… mechanistic insights into the roles of these individual molecules in phenotypic plasticity in …
However, these interactions have not been investigated from a dynamical systems perspective …
However, these interactions have not been investigated from a dynamical systems perspective …
Stochastic population dynamics of cancer stemness and adaptive response to therapies
… various processes underlying phenotypic plasticity such as … Such a dynamical systems
approach to elucidating patterns of … Such dynamic insights can be valuable in deciding …
approach to elucidating patterns of … Such dynamic insights can be valuable in deciding …
Quantifying cancer cell plasticity with gene regulatory networks and single-cell dynamics
SM Groves, V Quaranta - Frontiers in Network Physiology, 2023 - frontiersin.org
… Phenotypic plasticity of cancer cells can lead to complex cell … In dynamical systems theory,
plasticity is a weaker kind of … plasticity as multipotency by defining possible cell fates for each …
plasticity is a weaker kind of … plasticity as multipotency by defining possible cell fates for each …
Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again!
DJ Wooten, V Quaranta - … et Biophysica Acta (BBA)-Reviews on Cancer, 2017 - Elsevier
… tool to obtain a “rough and ready picture” that “cannot be interpreted rigorously” [17], it
was nonetheless developed within the mathematical context of dynamical systems theory. …
was nonetheless developed within the mathematical context of dynamical systems theory. …