Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates …
Background: Adaptor protein APPL1 plays a critical role in regulating both adiponectin and
insulin signaling pathways. Results: ER stress-induced APPL1 phosphorylation at Ser 430
blocks the insulin-sensitizing effect of APPL1 in a PKCα-dependent manner. Conclusion:
APPL1 phosphorylation at Ser 430 mediates ER stress-induced insulin resistance.
Significance: PKCα-mediated APPL1 phosphorylation could be a potential drug target for
the treatment of insulin resistance.
insulin signaling pathways. Results: ER stress-induced APPL1 phosphorylation at Ser 430
blocks the insulin-sensitizing effect of APPL1 in a PKCα-dependent manner. Conclusion:
APPL1 phosphorylation at Ser 430 mediates ER stress-induced insulin resistance.
Significance: PKCα-mediated APPL1 phosphorylation could be a potential drug target for
the treatment of insulin resistance.
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