Phosphorylation of c-jun mediated by MAP kinases
BJ Pulverer, JM Kyriakis, J Avruch, E Nikolakaki… - Nature, 1991 - nature.com
THE proto-oncogene c-jun is a component of the AP-1 transcription factor family involved in
the mediation of nuclear events elicited by extracellular stimuli1–3. The c-jun protein is
negatively regulated by phosphorylation of residues near the carboxy terminus which are
dephosphorylated in response to phorbol esters4. Here we identify two serine residues in
the amino terminal Al transactivation domain which are phosphorylated in response to a
variety of mitogens, phorbol esters and activated ras (ref. 5). We present evidence that …
the mediation of nuclear events elicited by extracellular stimuli1–3. The c-jun protein is
negatively regulated by phosphorylation of residues near the carboxy terminus which are
dephosphorylated in response to phorbol esters4. Here we identify two serine residues in
the amino terminal Al transactivation domain which are phosphorylated in response to a
variety of mitogens, phorbol esters and activated ras (ref. 5). We present evidence that …
[引用][C] Phosphorylation of c-jun mediated by MAP kinases
P BJ - Nature, 1991 - cir.nii.ac.jp
Phosphorylation of c-jun mediated by MAP kinases | CiNii Research … Phosphorylation of c-jun
mediated by MAP kinases …
mediated by MAP kinases …
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