Phototransformation and ecotoxicity of the drug Naproxen-Na
M DellaGreca, M Brigante, M Isidori, A Nardelli… - Environmental …, 2003 - Springer
Environmental Chemistry Letters, 2003•Springer
The phototransformation of naproxen Na in aqueous medium has been investigated.
Irradiation of the drug in drinking water affords seven photoproducts. Three of them are
dimeric photoproducts isolated for the first time. The compounds, isolated by
chromatographic processes, have been identified by spectroscopic means. The toxicity of
the photoproducts and the parent drug has been assayed on Daphnia magna and Vibrio
fischeri. The results indicate that some photoproducts are more toxic than naproxen.
Irradiation of the drug in drinking water affords seven photoproducts. Three of them are
dimeric photoproducts isolated for the first time. The compounds, isolated by
chromatographic processes, have been identified by spectroscopic means. The toxicity of
the photoproducts and the parent drug has been assayed on Daphnia magna and Vibrio
fischeri. The results indicate that some photoproducts are more toxic than naproxen.
Abstract
The phototransformation of naproxen Na in aqueous medium has been investigated. Irradiation of the drug in drinking water affords seven photoproducts. Three of them are dimeric photoproducts isolated for the first time. The compounds, isolated by chromatographic processes, have been identified by spectroscopic means. The toxicity of the photoproducts and the parent drug has been assayed on Daphnia magna and Vibrio fischeri. The results indicate that some photoproducts are more toxic than naproxen.
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