[PDF][PDF] Phytochemical characterization and cancer cell line cytotoxicity of Clitoria ternatea

S Deepika, CI Selvaraj, M Anbalagan - ||| Bangladesh Journal of …, 2018 - bdpsjournal.org
||| Bangladesh Journal of Pharmacology|||, 2018bdpsjournal.org
Ayurveda, a prominent traditional system, is using seed, leaf and root of Clitoria ternatea for
antidiabetic, anti-inflammatory, anti-depressant, cardiovascular disease, urinary problems,
hepatopathy, ulcer; as local anesthesia and also to act against laryngeal, colon and breast
carcinoma (Jain and Shukla, 2011). C. ternatea is an indigenous plant to the South East
Asia. Its phytoconstituents having bioactivities are previously reported as alkaloids (ethyl D-
galactopyranoside), triterpenoids like taraxerol and taraxerone from leaf (Singh and Tiwari …
Ayurveda, a prominent traditional system, is using seed, leaf and root of Clitoria ternatea for antidiabetic, anti-inflammatory, anti-depressant, cardiovascular disease, urinary problems, hepatopathy, ulcer; as local anesthesia and also to act against laryngeal, colon and breast carcinoma (Jain and Shukla, 2011). C. ternatea is an indigenous plant to the South East Asia. Its phytoconstituents having bioactivities are previously reported as alkaloids (ethyl D-galactopyranoside), triterpenoids like taraxerol and taraxerone from leaf (Singh and Tiwari, 2010); phenols like 3, 5, 7, 4-tetrahydroxyflavone-3-rhamoglycoside, syringic, epicatechin, gallic acid; flavonoids like flavonol glycosides (rutin), kaempferol glycosides (kaempferol-3-neohesperidoside), p-coumaric, rosmarinic, chlorogenic, apigenin, caffeic, ferulic, cinnamic acids and hydroxycinnamic acid derivatives; phytosterol such as β-sitosterol and campesterol from seed are considered valuable. Likewise, the hydrophilic seed extract cumulatively having these compounds were evaluated to show 92.8% cytotoxic to Hep2 laryngeal carcinoma cell line at 250 μg (Hamedi et al., 2014).
The fresh, tender, healthy leaf and fruit of C. ternatea were screened for the anti-oxidant, antibacterial and cytotoxic efficiency by various solvent extractions. The collected sample were authenticated and provided by Dr. NM Ganesh Babu, Foundation of Revitalization of Local Health Traditions, Bangalore. The plant metabolites were extracted using five different polarity-based solvents by soxhlet method to derive all types of available compounds in these particular plant parts. In the phytochemicals investigation, the primary and secondary metabolites were recognized (Table I).
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