Drug efflux pumps confer resistance upon bacteria to a wide range of antibiotics from
various classes. The expression of efflux pumps are also implicated in virulence and biofilm
formation. Moreover, organisms can only acquire resistance in the presence of active drug
efflux pumps. Therefore, efflux pump inhibitors (EPI s) are attractive compounds to reverse
multidrug resistance and to prevent the development of resistance in clinically relevant
bacterial pathogens. We investigated the potential of pure compounds isolated from plants …