Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation
B Gabryel, M Adamek, A Pudełko, A Małecki… - Neurotoxicology, 2002 - Elsevier
The aim of the present study was to establish whether piracetam (2-pyrrolidon-N-acetamide;
PIR) and vinpocetine (a vasoactive vinca alkaloid; VINP) are capable of protecting
astrocytes against hypoxic injury. Using the model of astrocyte cell culture we observed the
cells treated with PIR and VINP during and after in vitro simulated hypoxia. Cell viability was
determined by Live/Dead Viability/Cytotoxicity Assay Kit, LDH release assay and MTT
conversion test. Apoptotic cell death was distinguished by a method of Hoechst 33342 …
PIR) and vinpocetine (a vasoactive vinca alkaloid; VINP) are capable of protecting
astrocytes against hypoxic injury. Using the model of astrocyte cell culture we observed the
cells treated with PIR and VINP during and after in vitro simulated hypoxia. Cell viability was
determined by Live/Dead Viability/Cytotoxicity Assay Kit, LDH release assay and MTT
conversion test. Apoptotic cell death was distinguished by a method of Hoechst 33342 …
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