Primary Sjögren's syndrome (pSS) is a systemic auto-immune disease typified by dryness of
the mouth and eyes. A majority of patients with pSS have a type-I interferon (IFN)-signature,
which is defined as the increased expression of IFN-induced genes in circulating immune
cells and is associated with increased disease activity. As plasmacytoid dendritic cells (pDC)
are the premier type-I IFN-producing cells and are present at the site of inflammation, they
are thought to play a significant role in pSS pathogenesis. Considering the lack of data on …