Background The potential of Mendelian randomization studies is rapidly expanding due to: (i)
the growing power of genome-wide association study (GWAS) meta-analyses to detect …

… An assumption that is often required for pleiotropy robust Mendelian randomization is the
InSIDE assumption (instrument strength independent of direct effects). At a ‘population’ level, …

… We provide a simple but attractive method for weak and pleiotropy robust causal estimation
of sexually dimorphic traits on downstream outcomes, by combining several existing …

… If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one
trait, which in turn influences another (‘vertical pleiotropy’), then Mendelian randomization (MR) …

… , however limited methods are available for pleiotropy robust MVMR models. Furthermore, in
the … The major contribution of this article is to extend weak instrument and pleiotropy robust …

… The first contribution of this dissertation is the development of new methods for pleiotropy-robust
MR by leveraging sex specificity of phenotypes. These methods allow for more accurate …

… of Mendelian randomization (MR) to investigate causal relationships between pairs of
traits using SNPs as instrumental variables (IVs) based on observational data. In spite of the …

… exposures, limited methods are available for pleiotropy robust MVMR models 4,13 . Furthermore,
in … The major contribution of this paper is to extend weak instrument pleiotropy robust …

… While several ‘pleiotropy-robust’ methods attempt to model out pleiotropic effects by
assuming a particular model of genetic architecture, another strategy is to adjust for horizontal …

… and horizontal pleiotropy-robust MR methods associated with an IV-selection procedure.
The framework selected a method that involved horizontal pleiotropy (pleiotropy-robust method …