[HTML][HTML] Polyamine depletion has global effects on stress and virulence gene expression and affects HilA translation in Salmonella enterica serovar typhimurium
Polyamines are small cationic amines required for modulating multiple cell process,
including cell growth and DNA and RNA stability. In Salmonella polyamines are primarily
synthesized from L-arginine or L-ornithine. Based on a previous study, which demonstrated
that polyamines affect the expression of virulence gene in S. Typhimurium, we investigated
the role of polyamines in the global gene and protein expression in S. Typhimurium. The
depletion of polyamine biosynthesis led to down-regulation of genes encoding structural …
including cell growth and DNA and RNA stability. In Salmonella polyamines are primarily
synthesized from L-arginine or L-ornithine. Based on a previous study, which demonstrated
that polyamines affect the expression of virulence gene in S. Typhimurium, we investigated
the role of polyamines in the global gene and protein expression in S. Typhimurium. The
depletion of polyamine biosynthesis led to down-regulation of genes encoding structural …
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