Since the 1970s, polysaccharides such as dextran, dextrin, hyaluronic acid, hydroxyethyl
starch, and polysialic acid have been investigated as carriers for therapeutic protein and
peptide drugs in a wide range of clinical applications. Polysaccharides possess many
favorable features for the targeted delivery of protein and peptide drugs because they are
biodegradable, hydrophilic, and nontoxic. Given the reported potential of nonbiodegradable
polymers, such as polyethylene glycol, to induce lysosomal storage disease and induce …