The present clinical case report reveals an outbreak of severe scabies infestation along with tuberculosis among young children of Sahariya tribe of Central India. More predominately young children of the tribe were found severely infested with scabies. Some of them were also registered TB patients. Appropriate clinical tests were performed to identify the actual cause of outbreak and hematological analysis of blood sample was carried out to diagnose the clinical disease. ESR, lymphocyte counts and serum LDH content was found significantly (p<. 05) elevated in affected children and adult subjects, indicating the pathogenic infection (tuberculosis) and infestation (scabies) induced pathology. Weak immunity resulting from malnutrition, poor hygiene and lack of proper Medicare, in these rural and remote areas are the main predisposing factors till today. There is a need of regular follow up of local hygiene and medical facilities available in these areas followed by appropriate and timely treatment to them.