Population genetics of clonally transmissible cancers
M Ní Leathlobhair, RE Lenski - Nature Ecology & Evolution, 2022 - nature.com
Nature Ecology & Evolution, 2022•nature.com
Populations of cancer cells are subject to the same core evolutionary processes as
asexually reproducing, unicellular organisms. Transmissible cancers are particularly striking
examples of these processes. These unusual cancers are clonal lineages that can spread
through populations via physical transfer of living cancer cells from one host individual to
another, and they have achieved long-term success in the colonization of at least eight
different host species. Population genetic theory provides a useful framework for …
asexually reproducing, unicellular organisms. Transmissible cancers are particularly striking
examples of these processes. These unusual cancers are clonal lineages that can spread
through populations via physical transfer of living cancer cells from one host individual to
another, and they have achieved long-term success in the colonization of at least eight
different host species. Population genetic theory provides a useful framework for …
Abstract
Populations of cancer cells are subject to the same core evolutionary processes as asexually reproducing, unicellular organisms. Transmissible cancers are particularly striking examples of these processes. These unusual cancers are clonal lineages that can spread through populations via physical transfer of living cancer cells from one host individual to another, and they have achieved long-term success in the colonization of at least eight different host species. Population genetic theory provides a useful framework for understanding the shift from a multicellular sexual animal into a unicellular asexual clone and its long-term effects on the genomes of these cancers. In this Review, we consider recent findings from transmissible cancer research with the goals of developing an evolutionarily informed perspective on transmissible cancers, examining possible implications for their long-term fate and identifying areas for future research on these exceptional lineages.
nature.com
以上显示的是最相近的搜索结果。 查看全部搜索结果