Posaconazole concentrations in human tissues after allogeneic stem cell transplantation
O Blennow, E Eliasson, T Pettersson… - Antimicrobial agents …, 2014 - Am Soc Microbiol
O Blennow, E Eliasson, T Pettersson, A Pohanka, A Szakos, I El-Serafi, M Hassan…
Antimicrobial agents and chemotherapy, 2014•Am Soc MicrobiolFew data have been published regarding posaconazole tissue concentrations in humans.
We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven
patients who received posaconazole prophylaxis because of graft-versus-host disease. The
results were compared to plasma concentrations collected before death. Tissue
concentrations suggestive of an accumulation of posaconazole were found in the heart,
lung, liver, and kidney but not in the brain.
We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven
patients who received posaconazole prophylaxis because of graft-versus-host disease. The
results were compared to plasma concentrations collected before death. Tissue
concentrations suggestive of an accumulation of posaconazole were found in the heart,
lung, liver, and kidney but not in the brain.
Abstract
Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.
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