Chronic cerebral circulation insufficiency (CCCI) refers to a chronic decrease in cerebral
blood perfusion, which may lead to cognitive impairment, psychiatric disorders such as
depression, and acute ischemic stroke. Remote limb ischemic conditioning (RLIC), in which
the limbs are subjected to a series of transient ischemic attacks, can activate multiple
endogenous protective mechanisms to attenuate fatal ischemic injury to distant organs due
to acute ischemia, such as ischemic stroke. Recent studies have also reported that RLIC can …