Practice guidelines for the management of patients with histoplasmosis
J Wheat, G Sarosi, D McKinsey, R Hamill… - Clinical Infectious …, 2000 - academic.oup.com
J Wheat, G Sarosi, D McKinsey, R Hamill, R Bradsher, P Johnson, J Loyd, C Kauffman
Clinical Infectious Diseases, 2000•academic.oup.comObjective. The objective of this guideline is to provide recommendations for treating patients
with the more common forms of histoplasmosis. Participants and consensus process. A
working group of 8 experts in this field was convened to develop this guideline. The working
group developed and refined the guideline through a series of conference calls. Outcomes.
The goal of treatment is to eradicate the infection when possible, although chronic
suppression may be adequate for patients with AIDS and other serious immunosuppressive …
with the more common forms of histoplasmosis. Participants and consensus process. A
working group of 8 experts in this field was convened to develop this guideline. The working
group developed and refined the guideline through a series of conference calls. Outcomes.
The goal of treatment is to eradicate the infection when possible, although chronic
suppression may be adequate for patients with AIDS and other serious immunosuppressive …
Executive Summary
Objective. The objective of this guideline is to provide recommendations for treating patients with the more common forms of histoplasmosis.
Participants and consensus process. A working group of 8 experts in this field was convened to develop this guideline. The working group developed and refined the guideline through a series of conference calls.
Outcomes. The goal of treatment is to eradicate the infection when possible, although chronic suppression may be adequate for patients with AIDS and other serious immunosuppressive disorders. Other important outcomes are resolution of clinical abnormalities and prevention of relapse.
Evidence. The published literature on the management of histoplasmosis was reviewed. Controlled trials have been conducted that address the treatment of chronic pulmonary and disseminated histoplasmosis, but clinical experience and descriptive studies provide the basis for recommendations for other forms of histoplasmosis.
Value. Value was assigned on the basis of the strength of the evidence supporting treatment recommendations, with the highest value assigned to controlled trials, according to conventions established for developing practice guidelines.
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