Prediction of Gd (III) complex thermodynamic stability
R Uzal-Varela, A Rodríguez-Rodríguez, H Wang… - Coordination Chemistry …, 2022 - Elsevier
Gadolinium (III) complexes are widely employed as contrast agents in diagnostic magnetic
resonance imaging, and the development of new contrast agents remains a highly active
field. A key requisite for contrast agents is high thermodynamic stability of the complex to
ensure that the Gd (III) ion is not released in the body. Here we utilized published stability
constants spanning 20 orders of magnitude to develop empirical expressions based on
structural descriptors to predict the Gd (III)-ligand formation constant as well as pGd at pH …
resonance imaging, and the development of new contrast agents remains a highly active
field. A key requisite for contrast agents is high thermodynamic stability of the complex to
ensure that the Gd (III) ion is not released in the body. Here we utilized published stability
constants spanning 20 orders of magnitude to develop empirical expressions based on
structural descriptors to predict the Gd (III)-ligand formation constant as well as pGd at pH …
Prediction of Gd (Iii) Complex Thermodynamic Stability
A Rodríguez-Rodríguez, R Uzal-Varela… - Available at SSRN … - papers.ssrn.com
Gadolinium (III) complexes are widely employed as contrast agents in diagnostic magnetic
resonance imaging, and the development of new contrast agents remains a highly active
field. A key requisite for contrast agents is high thermodynamic stability of the complex to
insure that the Gd (III) ion is not released in the body. Here we utilized published stability
constants spanning 20 orders of magnitude to develop empirical expressions based on
structural descriptors to predict the Gd (III)-ligand formation constant as well as pGd at pH …
resonance imaging, and the development of new contrast agents remains a highly active
field. A key requisite for contrast agents is high thermodynamic stability of the complex to
insure that the Gd (III) ion is not released in the body. Here we utilized published stability
constants spanning 20 orders of magnitude to develop empirical expressions based on
structural descriptors to predict the Gd (III)-ligand formation constant as well as pGd at pH …
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