Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression
Inflammopharmacology, 2017•Springer
Introduction MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2
(VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral
lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP,
dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary
detections as the noninvasive tools were aimed in this study. Materials and methods
Histopathologic examinations were carried out to distinguish the patients with dysplastic …
(VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral
lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP,
dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary
detections as the noninvasive tools were aimed in this study. Materials and methods
Histopathologic examinations were carried out to distinguish the patients with dysplastic …
Introduction
MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study.
Materials and methods
Histopathologic examinations were carried out to distinguish the patients with dysplastic OLP and OSCC. Salivary microRNA expression analysis was performed using RT-qPCR. IL-6 and CRP levels were also measured in saliva via ELISA method. VEGFR-2 expression in various sections was evaluated using immunohistochemistry.
Results
A significant decrease in salivary microRNA-320a in dysplastic OLP and OSCC but not in OLP without dysplasia was found. VEGFR-2 visualization confirmed the increasing angiogenic process in these cases. A significant increase in IL-6 level was detected in cases with OLP, dysplastic OLP and OSCC. CRP levels also showed a significant increase in dysplastic OLP and OSCC. A positive correlation between IL-6 and CRP levels was found.
Conclusion
Identification of the salivary microRNA-320a and hs-CRP might provide a convenient noninvasive predictive tool for dysplastic OLP, whereas IL-6 could be a diagnostic and therapeutic target in both OLP without dysplasia and dysplastic OLP cases.
Springer
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