Preferential DNA damage prevention by the E. coli AidB gene: A new mechanism for the protection of specific genes
V Rippa, A Duilio, P di Pasquale, A Amoresano… - DNA repair, 2011 - Elsevier
aidB is one of the four genes of E. coli that is induced by alkylating agents and regulated by
Ada protein. Three genes (ada, alkA, and alkB) encode DNA repair proteins that remove or
repair alkylated bases. However, the role of AidB remains unclear despite extensive efforts
to determine its function in cells exposed to alkylating agents. The E. coli AidB protein was
identified as a component of the protein complex that assembles at strong promoters. We
demonstrate that AidB protein preferentially binds to UP elements, AT rich transcription …
Ada protein. Three genes (ada, alkA, and alkB) encode DNA repair proteins that remove or
repair alkylated bases. However, the role of AidB remains unclear despite extensive efforts
to determine its function in cells exposed to alkylating agents. The E. coli AidB protein was
identified as a component of the protein complex that assembles at strong promoters. We
demonstrate that AidB protein preferentially binds to UP elements, AT rich transcription …
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