Preferential binding of cisplatin to mitochondrial DNA of Chinese hamster ovary cells
OA Olivero, C Semino, A Kassim… - Mutation Research …, 1995 - Elsevier
Some chemical carcinogens localize preferentially in mitochondrial DNA (mtDNA) when
compared with genomic DNA (gDNA). Here we compare the ability of cisplatin (cis-
diamminedichloroplatimum [II]) to induce DNA adducts in both genomic and mtDNA of
Chinese hamster ovary (CHO) cells in culture. Cytotoxicity was examined by cell survival 4,
8 and 24 h afer exposure to 50 μM cisplatin. Cisplatin-DNA adducts were measured in DNA
from nuclear and mitochondrial fractions by dissociation-enhanced lanthanide …
compared with genomic DNA (gDNA). Here we compare the ability of cisplatin (cis-
diamminedichloroplatimum [II]) to induce DNA adducts in both genomic and mtDNA of
Chinese hamster ovary (CHO) cells in culture. Cytotoxicity was examined by cell survival 4,
8 and 24 h afer exposure to 50 μM cisplatin. Cisplatin-DNA adducts were measured in DNA
from nuclear and mitochondrial fractions by dissociation-enhanced lanthanide …
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