Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord …
D Rojas, JE Rager, L Smeester, KA Bailey… - Toxicological …, 2015 - academic.oup.com
Prenatal exposure to inorganic arsenic (iAs) is detrimental to the health of newborns and
increases the risk of disease development later in life. Here we examined a subset of
newborn cord blood leukocyte samples collected from subjects enrolled in the B iomarkers
of E xposure to AR senic (BEAR) pregnancy cohort in Gómez Palacio, Mexico, who were
exposed to a range of drinking water arsenic concentrations (0.456–236 µg/l). Changes in
iAs-associated DNA 5-methylcytosine methylation were assessed across 424 935 CpG sites …
increases the risk of disease development later in life. Here we examined a subset of
newborn cord blood leukocyte samples collected from subjects enrolled in the B iomarkers
of E xposure to AR senic (BEAR) pregnancy cohort in Gómez Palacio, Mexico, who were
exposed to a range of drinking water arsenic concentrations (0.456–236 µg/l). Changes in
iAs-associated DNA 5-methylcytosine methylation were assessed across 424 935 CpG sites …
Prenatal arsenic exposure and the epigenome: Identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord …
JD Rojas Rojas - 2014 - cdr.lib.unc.edu
Prenatal exposure to inorganic arsenic (iAs) is detrimental to the health of newborns and
increases the risk of disease later in life. Here we examined newborn cord blood leukocyte
samples from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico.
Changes in iAs-associated DNA methylation were compared to corresponding gene
expression levels and birth outcomes. 2,705 genes were identified with iAs-associated
differences in DNA methylation. In contrast to minimal association genome-wide, site …
increases the risk of disease later in life. Here we examined newborn cord blood leukocyte
samples from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico.
Changes in iAs-associated DNA methylation were compared to corresponding gene
expression levels and birth outcomes. 2,705 genes were identified with iAs-associated
differences in DNA methylation. In contrast to minimal association genome-wide, site …