Prenatal programming of insulin secretion in intrauterine growth restriction
KL Gatford, RA Simmons - Clinical obstetrics and gynecology, 2013 - journals.lww.com
Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal
models of IUGR. Several underlying mechanisms have been implicated, including
decreased expression of molecular regulators of β-cell mass and function, in some cases
shown to be due to epigenetic changes initiated by an adverse fetal environment. Alterations
in cell cycle progression contribute to loss of β-cell mass, whereas decreased islet
vascularity and mitochondrial dysfunction impair β-cell function in IUGR rodents. Animal …
models of IUGR. Several underlying mechanisms have been implicated, including
decreased expression of molecular regulators of β-cell mass and function, in some cases
shown to be due to epigenetic changes initiated by an adverse fetal environment. Alterations
in cell cycle progression contribute to loss of β-cell mass, whereas decreased islet
vascularity and mitochondrial dysfunction impair β-cell function in IUGR rodents. Animal …
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