[HTML][HTML] Pretransplant kidney transcriptome captures intrinsic donor organ quality and predicts 24-month outcomes
KJ Archer, E Bardhi, DG Maluf, J McDaniels… - American Journal of …, 2022 - Elsevier
With the development of novel prognostic tools derived from omics technologies, transplant
medicine is entering the era of precision medicine. Currently, there are no established
predictive biomarkers for posttransplant kidney function. A total of 270 deceased donor
pretransplant kidney biopsies were collected and posttransplant function was prospectively
monitored. This study first assessed the utility of pretransplant gene expression profiles in
predicting 24-month outcomes in a training set (n= 174). Nearly 600 differentially expressed …
medicine is entering the era of precision medicine. Currently, there are no established
predictive biomarkers for posttransplant kidney function. A total of 270 deceased donor
pretransplant kidney biopsies were collected and posttransplant function was prospectively
monitored. This study first assessed the utility of pretransplant gene expression profiles in
predicting 24-month outcomes in a training set (n= 174). Nearly 600 differentially expressed …
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