Amiodarone is a common anti-arrhythmic agent mostly used to treat and prevent different
kinds of arrhythmia with several considerable side effects, most commonly on the thyroid
gland. We aimed to assess the frequency of hypothyroidism among chronic amiodarone
users. PubMed/Medline, Web of Science, and Scopus databases were screened in the title
and abstract sections with no time limitation. Relevant published records reported
amiodarone-induced hypothyroidism (AIH) among patients with normal thyroid function at …

Background: Due to the importance of amiodarone-induced hyperthyroidism in patients with
heart failure, the purpose of the present systematic review and metaanalysis was to
determine the prevalence of thyroid dysfunction (hypothyroidism and hyperthyroidism) in
patients with heart disease who received amiodarone. Methods: Electronic databases
including Scopus, PubMed, Web of Science, and Science Direct were searched by two
investigators. To assess the heterogeneity between the included studies, the chi-square χ2; …