Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism

M Patil, S Belugin, J Mecklenburg, A Wangzhou… - IScience, 2019 - cell.com
Prolactin (PRL), which is involved in many physiologic functions… mechanism for female-selective
regulation of pain responses, which is mediated by Prlr signaling in sensory neurons via

An emerging role for prolactin in female-selective pain

Y Chen, E Navratilova, DW Dodick, F Porreca - Trends in neurosciences, 2020 - cell.com
mechanisms underlying chronic pain conditions. We now know that mechanisms promoting
pain … By contrast, spinal microglia and P2X4 receptors are required for these pain responses

Neuroendocrine mechanisms governing sex differences in hyperalgesic priming involve prolactin receptor sensory neuron signaling

C Paige, PA Barba-Escobedo… - Journal of …, 2020 - Soc Neuroscience
… This difference in PGE 2 response was dependent on both … Since the prolactin receptor
(Prlr) is regulated by reproductive … female-specific mechanism for the promotion of chronic pain

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

MJ Patil, SB Ruparel, MA Henry… - American Journal of …, 2013 - journals.physiology.org
… the activation of pain pathways by regulating immune system responses within peripheral …
mechanisms by which PRL and PRL-R regulate nociceptive processes in a plethora of painful

Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution

J Mecklenburg, A Wangzhou, AH Hovhannisyan… - Brain, behavior, and …, 2022 - Elsevier
… findings demonstrate an acute pain, female-selective effect of low … in mechanisms regulating
the transition to a chronic pain state and/or sex differences in resolution of pain mechanisms

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine

M Watanabe, CM Kopruszinski, A Moutal, D Ikegami… - Brain, 2022 - academic.oup.com
… circulating prolactin leading to female-selective sensitization of … receptor long and pain
responses to a normally innocuous … identifies a previously unknown mechanism that links the …

[PDF][PDF] Neuroendocrine mechanisms governing sex-differences in chronic pain involve prolactin receptor sensory neuron signaling

AN Akopian, TJ Price - scholar.archive.org
Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism
-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia …

Neuroendocrine mechanisms governing sex-differences in chronic pain involve prolactin receptor sensory neuron signaling

C Paige, PA Barba-Escobedo, J Mecklenburg, M Patil… - bioRxiv, 2020 - biorxiv.org
… This difference in PGE 2 response was dependent on both circulating estrogen and … of
hypersensitivity was regulated by testosterone. Since the prolactin receptor (Prlr) is regulated by …

[HTML][HTML] Sex differences in mechanisms of pain hypersensitivity

JS Mogil, M Parisien, SJ Esfahani… - … & Biobehavioral Reviews, 2024 - Elsevier
… non-opioid analgesic response and related phenomena like … of prolactin agonists, antagonists,
and a nociceptor-specific … of both sexes, the prolactin receptor protein was only found in …

Nociceptors are functionally male or female: from mouse to monkey to man

H Stratton, G Lee, M Dolatyari, A Ghetti, T Cotta… - Brain, 2024 - academic.oup.com
… differences in 8 mechanisms that promote pain in men and … sensitized by prolactin. In the
course of studies of sleep and … are strikingly consistent, with female selective effects of PRL and …