Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-γ-induced subunits LMP2 and LMP7
M Gaczynska, AL Goldberg, K Tanaka… - Journal of biological …, 1996 - ASBMB
Most antigenic peptides presented on major histocompatibility complex class I molecules
are generated by proteasomes. Interferon-γ, which stimulates antigen presentation, induces
new proteasome β-subunits LMP2 and LMP7, which replace the homologous β-subunits Y
(δ) and X (ε). As a result, the capacity of the proteasome to cleave model peptides increases
after hydrophobic and basic residues and falls after acidic residues. To clarify the function of
these subunits, we examined the effects of overexpressing subunits X (δ) and Y (ε) …
are generated by proteasomes. Interferon-γ, which stimulates antigen presentation, induces
new proteasome β-subunits LMP2 and LMP7, which replace the homologous β-subunits Y
(δ) and X (ε). As a result, the capacity of the proteasome to cleave model peptides increases
after hydrophobic and basic residues and falls after acidic residues. To clarify the function of
these subunits, we examined the effects of overexpressing subunits X (δ) and Y (ε) …