Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation: effects of Alzheimer disease and identification of lipoxidation targets
R Pamplona, E Dalfó, V Ayala, MJ Bellmunt… - Journal of Biological …, 2005 - ASBMB
Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and
lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the
amount of structurally characterized probes for these reactions is lacking and could
overcome the lack of specificity derived from measurement of 2, 4-dinitrophenylhydrazine
reactive carbonyls. Consequently we analyzed (i) the presence and concentrations of
glutamic and aminoadipic semialdehydes, N ϵ-(carboxymethyl)-lysine, N ϵ-(carboxyethyl) …
lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the
amount of structurally characterized probes for these reactions is lacking and could
overcome the lack of specificity derived from measurement of 2, 4-dinitrophenylhydrazine
reactive carbonyls. Consequently we analyzed (i) the presence and concentrations of
glutamic and aminoadipic semialdehydes, N ϵ-(carboxymethyl)-lysine, N ϵ-(carboxyethyl) …
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