过去一年中添加的文章，按日期排序
Indisulam Treatment Degrades Rbm39 and Inhibits Acute Megakaryoblastic Leukemia by Affecting Alternative Splicing of Zmynd8
Y Yang, Z Li, Y Yang, P Xiao, Z He, Z Zhang, Y Li, L Shi… - papers.ssrn.com
8 天前 - … PROteolysis-TArgeting Chimera (PROTAC) drug indisulam, which targets the splicing
factor RNA binding motif protein … indisulam compared with other tumor types. Furthermore…
factor RNA binding motif protein … indisulam compared with other tumor types. Furthermore…
The emerging role of targeted protein degradation to treat and study cancer
MH Brodermann, EK Henderson… - The Journal of …, 2024 - Wiley Online Library
9 天前 - … of targeted protein degraders include molecular glues and proteolysis targeting
chimeras (… However, contrary to classical PROTAC or SNIPER heterobifunctional protein …
chimeras (… However, contrary to classical PROTAC or SNIPER heterobifunctional protein …
Powering Up Targeted Protein Degradation Through Active and Passive Tumour-Targeting Strategies: Current and Future Scopes
J Venkatesan, D Murugan… - Available at SSRN … - papers.ssrn.com
15 天前 - … therapeutic intervention of cancers and other diseases. One such approach involves
the exploration of proteolysis targeting chimeras (… of various PROTAC molecules in clinical …
the exploration of proteolysis targeting chimeras (… of various PROTAC molecules in clinical …
Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design
16 天前 - … as a promising therapeutic approach for cancer and other … for TPD is Proteolysis
Targeting Chimeras (PROTACs, or … the PROTAC-induced targeted protein degradation (TPD), …
Targeting Chimeras (PROTACs, or … the PROTAC-induced targeted protein degradation (TPD), …
Exploration of Potential Cyclin-dependent Kinases and their Inhibitors to Combat Abnormal Signalling and Cancer
P Pilania, S Nandi, DK Meena… - … Transduction Therapy, 2024 - ingentaconnect.com
21 天前 - … been studying the proteolysis-targeting chimera (PROTAC) … targets, making it a
promising method for targeted protein … as induced protein degradation is hopeful and alluring. …
promising method for targeted protein … as induced protein degradation is hopeful and alluring. …
PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
ATS Vicente, JAR Salvador - MedComm, 2024 - Wiley Online Library
21 天前 - … Developed against a wide range of cancer targets, they … PROTAC-mediated
degradation of leukemia-associated … few years, targeted protein degradation using bifunctional …
degradation of leukemia-associated … few years, targeted protein degradation using bifunctional …
Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation
S Wang, Z Feng, C Qu, S Yu, H Zhang… - Journal of Medicinal …, 2024 - ACS Publications
21 天前 - … Proteolysis targeting chimera (PROTAC) technology is an … complex that leads to
targeted protein degradation, and its … of PROTAC molecules while imparting selectivity for tumor …
targeted protein degradation, and its … of PROTAC molecules while imparting selectivity for tumor …
Hydrophobic tagging of small molecules: an overview of the literature and future outlook
Y Zhou, F Zhou, S Xu, D Shi, D Ding… - Expert Opinion on …, 2024 - Taylor & Francis
25 天前 - … as a highly promising targeted protein degradation (TPD) … development of proteolysis
targeting chimeras (PROTAC) and … tumors, rendering it an ideal target for cancer therapy […
targeting chimeras (PROTAC) and … tumors, rendering it an ideal target for cancer therapy […
Design, synthesis, and evaluation of BCL‐2 targeting PROTACs
27 天前 - … targeted protein degradation has encountered significant advancements in recent
years, with proteolysis-targeting chimeras … as PROTAC C5 were inactive after treatment with 1 …
years, with proteolysis-targeting chimeras … as PROTAC C5 were inactive after treatment with 1 …
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
LM Kelly, JC Rutter, KH Lin, F Ling, M Duchmann… - Nature Cancer, 2024 - nature.com
28 天前 - … proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically
degrades … in targeted protein degradation, we developed a PROTAC system in which AZ2, …
degrades … in targeted protein degradation, we developed a PROTAC system in which AZ2, …