过去一年中添加的文章，按日期排序
[HTML][HTML] PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer
120 天前 - … target BCL-xL in tumors, while sparing platelets, by utilizing proteolysis-targeting
chimeras (… Due to the reduced ternary complex formation, target protein degradation is …
chimeras (… Due to the reduced ternary complex formation, target protein degradation is …
mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation
X Xue, C Zhang, X Li, J Wang, H Zhang, Y Feng… - MedComm, 2024 - Wiley Online Library
132 天前 - … that m-PROTAC led to significant tumor regression in the 4T1 … m-PROTAC as a
promising approach for targeted protein … proteolysis-targeting chimera (m-PROTAC)-1 treatment …
promising approach for targeted protein … proteolysis-targeting chimera (m-PROTAC)-1 treatment …
A PROTAC Augmenter for Photo‐Driven Pyroptosis in Breast Cancer
D Huang, Y Zou, H Huang, J Yin, S Long… - Advanced …, 2024 - Wiley Online Library
134 天前 - … Proteolysis targeting chimera (PROTAC) has recently … knockdown of target proteins
in disease treatment. The … of BRD4 by MZ1 and indicated that the protein degradation effect …
in disease treatment. The … of BRD4 by MZ1 and indicated that the protein degradation effect …
Potential of the nanoplatform and PROTAC interface to achieve targeted protein degradation through the Ubiquitin–Proteasome system
H Xie, C Zhang - European Journal of Medicinal Chemistry, 2024 - Elsevier
149 天前 - … targeted protein degradation (TPD) strategies. In particular, proteolysis targeting
chimeras … to more effective degradation of target proteins and thus inhibiting tumor proliferation …
chimeras … to more effective degradation of target proteins and thus inhibiting tumor proliferation …
The BET inhibitor GNE-987 effectively induces anti-cancer effects in T-cell acute lymphoblastic leukemia by targeting enhancer regulated genes
J Yu, Y Yang, R Zhou, Y Tao, F Zhu, W Jiao… - …, 2024 - academic.oup.com
149 天前 - … limitations, proteolysis-targeting chimeras (PROTAC) … with ligands that recognize
target proteins through flexible … -987-induced BRD protein degradation, we administered the …
target proteins through flexible … -987-induced BRD protein degradation, we administered the …
PROTAC-biomacromolecule conjugates for precise protein degradation in cancer therapy: A review
C Wang, Y Zhang, W Yu, J Xu, D Xing - International Journal of Biological …, 2024 - Elsevier
151 天前 - … Proteolysis targeting chimera (PROTAC) technology is a promising new mode of
targeted protein degradation with … implications for the clinical treatment of different diseases. …
targeted protein degradation with … implications for the clinical treatment of different diseases. …
[HTML][HTML] Therapies for the treatment of advanced/metastatic estrogen receptor-positive breast cancer: current situation and future directions
155 天前 - … exploring new therapeutic strategies such as targeted protein degradation and
covalent … antagonists (SERCAs), proteolysis targeting chimera (PROTAC) degraders, and …
covalent … antagonists (SERCAs), proteolysis targeting chimera (PROTAC) degraders, and …
Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation
J Miao, ZY Zhang - ChemMedChem, 2024 - Wiley Online Library
164 天前 - … proteolysistargeting chimera (PROTAC) technology offers an alternative approach
to target … potential targets for various human diseases such as cancer, diabetes, and obesity. …
to target … potential targets for various human diseases such as cancer, diabetes, and obesity. …
[HTML][HTML] Targeting CDK9 in Cancer: An Integrated Approach of Combining In Silico Screening with Experimental Validation for Novel Degraders
170 天前 - … compounds for targeted protein degradation, offering a … realm of Proteolysis-Targeting
Chimeras (PROTACs) [14]. This … , and PROTAC-mediated protein degradation, seeks to …
Chimeras (PROTACs) [14]. This … , and PROTAC-mediated protein degradation, seeks to …
[HTML][HTML] PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer
KA Rutherford, KJ McManus - Molecular Cancer Therapeutics, 2024 - AACR
172 天前 - … Proteolysis targeting chimeras (PROTAC) are an emerging precision … cycles of target
proteins and the basis of PROTAC activity. A, The sequential … Targeted protein degradation …
proteins and the basis of PROTAC activity. A, The sequential … Targeted protein degradation …