Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A
Circadian clocks keep time via~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-
CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback
loop components whose transcriptional status varies over a circadian cycle. Although
changes in the state of activators and repressors has been characterized, how their status is
translated to transcriptional activity is not understood. We used mass spectrometry to identify
proteins that interact with GFP-tagged CLK (GFP-CLK) in fly heads at different times of day …
CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback
loop components whose transcriptional status varies over a circadian cycle. Although
changes in the state of activators and repressors has been characterized, how their status is
translated to transcriptional activity is not understood. We used mass spectrometry to identify
proteins that interact with GFP-tagged CLK (GFP-CLK) in fly heads at different times of day …
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