Frogs from the extensive amphibian family Hylidae are a rich source of peptides with
therapeutic potential. Peptidomic analysis of norepinephrine-stimulated skin secretions from
the Giant Gladiator Treefrog Boana boans (Hylidae: Hylinae) collected in Trinidad led to the
isolation and structural characterization of five host-defense peptides with limited structural
similarity to figainin 2 and picturin peptides from other frog species belonging to the genus
Boana. In addition, the skin secretions contained high concentrations of tryptophyllin-BN …

The amphibian family Leptodactylidae is divided into three sub-families: Leiuperinae,
Leptodactylinae, and Paratelmatobiinae. Host-defense peptides (HDPs) present in the skins
of frogs belonging to the Leptodactylinae have been studied extensively, but information is
limited regarding peptides from Leiuperinae species. Peptidomic analysis of norepinephrine-
stimulated skin secretions from the Tungara frog Engystomops pustulosus (Leiuperinae)
collected in Trinidad led to the isolation and structural characterization of previously …