… we can quantitatively predict human clinical PK for two different drugs using two different …
organ chips functioned in a physiologically relevant way when fluidically linked in this study. …

… we can quantitatively predict human clinical PK for two different drugs using two different …
organ chips functioned in a physiologically relevant way when fluidically linked in this study. …

… that we can quantitatively predict human clinical PK for two different drugs using two different
… functioned in a physiologically relevant way when fluidically linked in the present study. …

… If microfluidic technology is employed, fluidic channels can … the combined model, the PK
profile of a drug gives the drug … also enables the quantitative study of the mechanism of a drug’s …

… drugs/metabolites and thus data-rich quantitative PK … be fluidically coupled with circulating
common medium without compromising MPS functionality. More specifically, we quantified …

… enables quantitative prediction of the dose–response … to review how microscale technology
combined with cell cultures, … through fluidic channels, covering the hydrogel matrix on top. …

… pharmacokinetic (PBPK) model and contains mammalian cells cultured in interconnected
microchambers to represent key organs linked through … systems in which fluidic movement can …

… European integrated Predict-IV to pharmacokinetic modeling … further into quantitative risk
assessment and dose–response … stress in human kidney cells in vivo, we coupled the above …

… , as well as mathematical approaches that can be combined … across the membrane is
quantified. The main drawbacks of … cells to an appropriate level of fluidic shear stress resulted in …

… of drugs is the need for a quantitative approach to predict the … recapitulated human metabolism
and clearance responses to … In contrast, the fluidic coupling of vascularized Organ Chips …