Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70

JH Bae, JY Kim, MJ Kim, SH Chang… - Journal of …, 2010 - journals.lww.com
It is known that treatments with heat shock, some anticancer drugs, and ionizing radiation
increase the expression of heat-shock proteins (HSPs) and natural killer group 2D (NKG2D)
ligands in tumor cells. The increased HSPs may make the tumor cells resistant to apoptosis
and reduction of HSPs may make the tumor cells more susceptible to natural killer (NK)-cell
mediated lysis of tumor cells. In this study, we investigated whether quercetin which has
inhibitory activities against heat-shock factor, protein kinase C, nuclear factor-κB, and …
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