Quinolizidine alkaloids from the roots of Sophora flavescens
JC Li, ZJ Zhang, D Liu, MY Jiang, RT Li… - Natural Product …, 2022 - Taylor & Francis
JC Li, ZJ Zhang, D Liu, MY Jiang, RT Li, HM Li
Natural Product Research, 2022•Taylor & FrancisSeventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were
isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was
elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The
NMR data of (-)-Δ 7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported
for the first time. In addition,(+)-sophoranol (4) exhibited moderate inhibition on
lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages …
isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was
elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The
NMR data of (-)-Δ 7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported
for the first time. In addition,(+)-sophoranol (4) exhibited moderate inhibition on
lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages …
Abstract
Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL.
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