Lung cancer remains the leading cause of cancer‐related death due to poor treatment
responses and resistance arising from tumour heterogeneity. Here, we show that adverse
prognosis associated with epigenetic silencing of the tumour suppressor RASSF 1A is due
to increased deposition of extracellular matrix (ECM), tumour stiffness and metastatic
dissemination in vitro and in vivo. We find that lung cancer cells with RASSF 1A promoter
methylation display constitutive nuclear YAP 1 accumulation and expression of prolyl 4 …

Lung cancer remains the leading cause of cancer‐related death due to poor treatment
responses and resistance arising from tumour heterogeneity. Here, we show that adverse
prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to
increased deposition of extracellular matrix (ECM), tumour stiffness and metastatic
dissemination in vitro and in vivo. We find that lung cancer cells with RASSF1A promoter
methylation display constitutive nuclear YAP1 accumulation and expression of prolyl 4 …