[HTML][HTML] RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer
PIWI-interacting small non-coding RNAs (piRNAs) are genetic and epigenetic regulatory
factors in germline cells, where they maintain genome stability, are involved in RNA
silencing and regulate gene expression. We found that the piRNA biogenesis and effector
pathway are present in human breast cancer (BC) cells and, analyzing smallRNA-Seq data
generated from BC cell lines and tumor biopsies, we identified> 100 BC piRNAs, including
some very abundant and/or differentially expressed in mammary epithelial compared to BC …
factors in germline cells, where they maintain genome stability, are involved in RNA
silencing and regulate gene expression. We found that the piRNA biogenesis and effector
pathway are present in human breast cancer (BC) cells and, analyzing smallRNA-Seq data
generated from BC cell lines and tumor biopsies, we identified> 100 BC piRNAs, including
some very abundant and/or differentially expressed in mammary epithelial compared to BC …
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