… To test the idea that rapamycin retards aging in mice, we evaluated a series of age-sensitive …
-old mice, that is, at an age where relatively few mice in the control or rapamycin-treated …

… Also of interest will be the effects on lifespan of rapamycin in male 129/sv mice,
particularly in light of the sex difference in the longevity of s6K1-knockout mice. studies of …

… then is whether the drug slows mammalian aging or if it has … the main cause of death in many
mouse strains. Here, we review … of rapamycin’s lifespan effects in aging 129/Sv female mice …

… To illustrate this point, we should consider two recent studies which aimed at assessing
whether rapamycin slows aging in mice by quantifying the effects of the 14 ppm rapamycin diet …

… rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities.
Aging is… Note: This extension is impressive given that (a) effects of rapamycin in male mice …

… if this compound actually slows the rate of aging in mammals. … aging phenotypes, which
we performed to determine whether rapamycin slows the rate of aging in male C57BL/6J mice…

… , coordination, or balance in aging mice, rapamycin-fed mice had either enhanced function
or … We did not observe some effects such as slower loss of spontaneous activity, which have …

… and prevent age-related diseases by slowing down aging. Since that time many … , rapamycin
improves immunity of old mice, protects aging mice from infections32,40 and protects mice …

… Nevertheless, important questions remain regarding the optimal dose, duration, and
mechanisms of action in the context of healthy aging. Here we show that 3 months of …

… rapamycin slows growth, it should also slow aging if aging is a continuation of growth. In
fact, it does just that; rapamycin … comparing the numerous studies in mouse models. It should …