Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity
L Berod, P Stüve, F Varela, J Behrends, M Swallow… - PLoS …, 2014 - journals.plos.org
The development of an effective vaccine against tuberculosis (Tb) represents one of the
major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin
(BCG), the only vaccine available at present, is mostly effective at preventing disseminated
Tb in children, but shows variable protection against pulmonary Tb, the most common form
in adults. The reasons for this poor efficacy are not completely understood, but there is
evidence that T regulatory cells (Tregs) might be involved. Similarly, Tregs have been …
major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin
(BCG), the only vaccine available at present, is mostly effective at preventing disseminated
Tb in children, but shows variable protection against pulmonary Tb, the most common form
in adults. The reasons for this poor efficacy are not completely understood, but there is
evidence that T regulatory cells (Tregs) might be involved. Similarly, Tregs have been …
[PDF][PDF] Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg
L Berod, P Stüve, F Varela, J Behrends, M Swallow - 2014 - academia.edu
The development of an effective vaccine against tuberculosis (Tb) represents one of the
major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin
(BCG), the only vaccine available at present, is mostly effective at preventing disseminated
Tb in children, but shows variable protection against pulmonary Tb, the most common form
in adults. The reasons for this poor efficacy are not completely understood, but there is
evidence that T regulatory cells (Tregs) might be involved. Similarly, Tregs have been …
major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin
(BCG), the only vaccine available at present, is mostly effective at preventing disseminated
Tb in children, but shows variable protection against pulmonary Tb, the most common form
in adults. The reasons for this poor efficacy are not completely understood, but there is
evidence that T regulatory cells (Tregs) might be involved. Similarly, Tregs have been …
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