过去一年中添加的文章，按日期排序
Inhibition of Parkinson's disease-related LRRK2 by type-I and type-II kinase inhibitors: Activity and structures
197 天前 - … By in vivo phenotypic assays we demonstrate that this conformational switch is …
rational development of LRRK2 kinase inhibitors covering both canonical inhibitor binding …
rational development of LRRK2 kinase inhibitors covering both canonical inhibitor binding …
[HTML][HTML] Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM
213 天前 - … and a framework for understanding LRRK2 activation and for rational drug design.
… the type I-bound active-like and type II-bound inactive conformations in our analysis for the …
… the type I-bound active-like and type II-bound inactive conformations in our analysis for the …
[PDF][PDF] Research Article Molecular Dynamics Simulation and Pharmacoinformatic Integrated Analysis of Bioactive Phytochemicals from Azadirachta indica (Neem) to …
A Abdullah, P Biswas, M Sahabuddin, A Mubasharah… - 2023 - academia.edu
284 天前 - … •based rational drug design are two in … binding pocket conformational states to
produce a specific signaling profile. An agonist, for instance, keeps active states above inactive …
produce a specific signaling profile. An agonist, for instance, keeps active states above inactive …