Reappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumarate hydratase–deficient renal cell carcinoma
C Ohe, SC Smith, D Sirohi, M Divatia… - The American journal …, 2018 - journals.lww.com
Renal medullary carcinomas (RMCs) and collecting duct carcinomas (CDCs) are rare
subsets of lethal high-stage, high-grade distal nephron-related adenocarcinomas with a
predilection for the renal medullary region. Recent findings have established an emerging
group of fumarate hydratase (FH)-deficient tumors related to hereditary leiomyomatosis and
renal cell carcinoma (HLRCC-RCCs) syndrome within this morphologic spectrum. Recently
developed, reliable ancillary testing has enabled consistent separation between these tumor …
subsets of lethal high-stage, high-grade distal nephron-related adenocarcinomas with a
predilection for the renal medullary region. Recent findings have established an emerging
group of fumarate hydratase (FH)-deficient tumors related to hereditary leiomyomatosis and
renal cell carcinoma (HLRCC-RCCs) syndrome within this morphologic spectrum. Recently
developed, reliable ancillary testing has enabled consistent separation between these tumor …
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