Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects

SH Kiaie, N Majidi Zolbanin, A Ahmadi… - Journal of …, 2022 - Springer
Journal of nanobiotechnology, 2022Springer
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of
treatment modality to a large extent. Although mRNA-LNP vaccine platforms for the COVID-
19 pandemic demonstrated high efficiency, safety and adverse effects challenges due to the
uncontrolled immune responses and inappropriate pharmacological interventions could limit
this tremendous efficacy. The current study reveals the interplay of immune responses with …
Abstract
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of treatment modality to a large extent. Although mRNA-LNP vaccine platforms for the COVID-19 pandemic demonstrated high efficiency, safety and adverse effects challenges due to the uncontrolled immune responses and inappropriate pharmacological interventions could limit this tremendous efficacy. The current study reveals the interplay of immune responses with LNP compositions and characterization and clarifies the interaction of mRNA-LNP therapeutics with dendritic, macrophages, neutrophile cells, and complement. Then, pharmacological profiles for mRNA-LNP delivery, including pharmacokinetics and cellular trafficking, were discussed in detail in cancer types and infectious diseases. This review study opens a new and vital landscape to improve multidisciplinary therapeutics on mRNA-LNP through modulation of immunopharmacological responses in clinical trials.
Graphical Abstract
Springer
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