23 天前 - Hydrocephalus is one of the most common neurological disorders, but pharmacotherapy
options are currently lacking due to the complex pathogenesis. The blood-CSF barrier (…

70 天前 - … vivo, we develop a siRNA-loaded bovine serum albumin nanoparticle for targeted
delivery. Nanoparticle-mediated siRNA delivery successfully silences endomucin expression …

74 天前 - … and selectivity to deliver siRNA-HIF-1α (siHIF1α) and silibinin (SLB) payloads to
hepatocytes. The optimized SLB/siHIF1α-LNPs mediates great siRNA delivery and transfection …

89 天前 - … the various applications of nanoparticle-mediated oligonucleotide delivery in a variety
of … Such formulations have proven effective in vitro for siRNA delivery [124] and in vivo for …

110 天前 - … Nanoparticle-mediated pulmonary delivery of biologics can facilitate both local
and … siRNA delivery via SLNs has been explored for more complex therapeutic targets like …

110 天前 - … delivery strategy for liver-targeted siRNA delivery and currently represent the most
advanced platform for delivery of … to promote cytosolic delivery of both mRNA and siRNA after …

116 天前 - … Nanoparticle-mediated delivery of small molecules is often explored for glioma
therapy since the majority of small molecules are excluded from the brain, however using …

133 天前 - … can effectively target these gene fusions, however effective delivery and siRNA …
and effectively deliver siRNAs to target cells. Here, we investigated the delivery of siRNA’s …

151 天前 - … In the 2000s, the siRNA delivery concept was initiated for specific target gene … help
of the lipid nanoparticle-mediated delivery system. siRNA must be delivered in the cytoplasm …

159 天前 - … In addition, this review will thoroughly evaluate the safety, specificity, and
scalability of LNP-mediated siRNA delivery. It will address important factors that are crucial for …