Potato (Solanum tuberosum L.) is an annual dicotyledonous tuber crop originating from the Americas and now distributed all over the world. A member of the Solanaceae family, potato is the fourth most produced food crop and the first non-cereal crop in the world. Potato is a staple food with its high potentiality in fighting malnutrition in the world since potato tubers are known sources of vitamins, proteins, carbohydrates and minerals. Moreover, it generates higher yield compared to the other crops; hence, it is one of the most notable crops to eliminate hunger and poverty. Therefore, sustainable potato production is important for food security and social welfare in future climate-change scenarios. However, it is very sensitive to environmental conditions and climate change due to its shallow root system. Therefore, future potato breeding programs should focus on enhancement of abiotic and biotic stress tolerance by utilizing the natural germplasm conserved in different gene banks. Moreover, potato breeding should benefit from the effectiveness and ease of molecular techniques such as marker-assisted selection, genome-wide association studies, functional genomics and transgenics. Development of new potato varieties can also be achieved via genetic engineering and genome editing. Disease-free potato seed production requires integration of tissue culture methods in plant breeding. As a staple food for millions, the potato has an extraordinarily rich past, and a bright future. The demand for potato will increase in future, which will be the driving force behind the potato research.