Recovery of infective virus particles in ion-exchange and hydrophobic interaction monolith chromatography is influenced by particle charge and total-to-infective …
Viral particles are used in medical applications as vaccines or gene therapy vectors. In order
to obtain product of high purity, potency and safety for medical use purification of virus
particles is a prerequisite, and chromatography is gaining increased attention to meet this
aim. Here, we report on the use of ion-exchange and hydrophobic interaction
chromatography on monolithic columns for purification of mumps virus (MuV) and measles
virus (MeV). Efficiency of the process was monitored by quantification of infective virus …
to obtain product of high purity, potency and safety for medical use purification of virus
particles is a prerequisite, and chromatography is gaining increased attention to meet this
aim. Here, we report on the use of ion-exchange and hydrophobic interaction
chromatography on monolithic columns for purification of mumps virus (MuV) and measles
virus (MeV). Efficiency of the process was monitored by quantification of infective virus …
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