[HTML][HTML] Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment
The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated
macrophages (TAMs), which are abundant in the TME. TAMs are crucial drivers of tumor
progression, metastasis, and resistance to therapy. Intra-and inter-tumoral spatial
heterogeneities are potential keys to understanding the relationships between
subpopulations of TAMs and their functions. Antitumor M1-like and pro-tumor M2-like TAMs …
defined due to a lack of understanding regarding the function of tumor-associated
macrophages (TAMs), which are abundant in the TME. TAMs are crucial drivers of tumor
progression, metastasis, and resistance to therapy. Intra-and inter-tumoral spatial
heterogeneities are potential keys to understanding the relationships between
subpopulations of TAMs and their functions. Antitumor M1-like and pro-tumor M2-like TAMs …
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