Redox instability and hemin loss of mutant sperm whale myoglobins induced by 4-hydroxynonenal in vitro
The effects of 4-hydroxy-2-nonenal (HNE) on redox stability of Oxy-and Deoxy-wild-type
(WT) and recombinant sperm whale myoglobins (P88H/Q152H, L29F, H97A, and H64F) and
hemin loss from Met-myoglobin (Mb) were investigated. HNE induced greater redox
instability in WT and mutant Mbs compared to controls (p< 0.05). The extent of HNE-induced
OxyMb oxidation was lesser in L29F (p< 0.05) and greater in H97A and P88H/Q152H than
in WT (p< 0.05). H64F DeoxyMb was more redox stable than WT DeoxyMb in the presence …
(WT) and recombinant sperm whale myoglobins (P88H/Q152H, L29F, H97A, and H64F) and
hemin loss from Met-myoglobin (Mb) were investigated. HNE induced greater redox
instability in WT and mutant Mbs compared to controls (p< 0.05). The extent of HNE-induced
OxyMb oxidation was lesser in L29F (p< 0.05) and greater in H97A and P88H/Q152H than
in WT (p< 0.05). H64F DeoxyMb was more redox stable than WT DeoxyMb in the presence …
[引用][C] Redox Instability and Hemin Loss of Mutant Sperm Whale Myoglobins Induced by 4-Hydroxynonenal in Vitro
T Nantawat, F Cameron, Y Shuang, R Ranjith - 2012
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