Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats

Z Wu, Y Yu, Y Wu, C Patch, A Szabo, XF Huang - Brain research bulletin, 2013 - Elsevier
High-fat (HF) diet and obesity are risk factors for a number of mental health problems
including depression, cognitive dysfunction, dementia, and neurodegenerative diseases.
Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study
examined H1R receptor binding density in the brain of male rats fed a high-saturated fat
(HF) diet, as well as the effect of docosahexaenoic acid (DHA), galacto-oligosaccharide
(GOS) and resistant starch (RS) supplementation of HF diet. Alterations of H1R expression …

Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats.

WZX Wu ZhiXiang, YYH Yu YingHua, WYZ Wu YiZhen… - 2013 - cabidigitallibrary.org
High-fat (HF) diet and obesity are risk factors for a number of mental health problems
including depression, cognitive dysfunction, dementia, and neurodegenerative diseases.
Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study
examined H1R receptor binding density in the brain of male rats fed a high-saturated fat
(HF) diet, as well as the effect of docosahexaenoic acid (DHA), galacto-oligosaccharide
(GOS) and resistant starch (RS) supplementation of HF diet. Alterations of H1R expression …
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