Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
Increasing evidence points to soluble assemblies of aggregating proteins as a major
mediator of neuronal and synaptic dysfunction. In Alzheimer disease (AD), soluble amyloid-
β (Aβ) appears to be a key factor in inducing synaptic and cognitive abnormalities. Here we
report the novel finding that soluble tau also plays a role in the cognitive decline in the
presence of concomitant Aβ pathology. We describe improved cognitive function following a
reduction in both soluble Aβ and tau levels after active or passive immunization in advanced …
mediator of neuronal and synaptic dysfunction. In Alzheimer disease (AD), soluble amyloid-
β (Aβ) appears to be a key factor in inducing synaptic and cognitive abnormalities. Here we
report the novel finding that soluble tau also plays a role in the cognitive decline in the
presence of concomitant Aβ pathology. We describe improved cognitive function following a
reduction in both soluble Aβ and tau levels after active or passive immunization in advanced …
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