Regio-and stereoselective alkylboration of endocyclic olefins enabled by nickel catalysis
C Ding, Y Ren, C Sun, J Long, G Yin - Journal of the American …, 2021 - ACS Publications
C Ding, Y Ren, C Sun, J Long, G Yin
Journal of the American Chemical Society, 2021•ACS PublicationsWhereas there is a significant interest in the rapid construction of diversely substituted
saturated heterocycles, direct and modular access is currently limited to the mono-, 2, 3-, or
3, 4-substitution pattern. This Communication describes the straightforward and modular
construction of 2, 4-substituted saturated heterocycles from readily available materials in a
highly stereo-and regioselective manner, which sets the stage for numerous readily
accessible drug motifs. The strategy relies on chain walking catalysis.
saturated heterocycles, direct and modular access is currently limited to the mono-, 2, 3-, or
3, 4-substitution pattern. This Communication describes the straightforward and modular
construction of 2, 4-substituted saturated heterocycles from readily available materials in a
highly stereo-and regioselective manner, which sets the stage for numerous readily
accessible drug motifs. The strategy relies on chain walking catalysis.
Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis.
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